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  • Call for new policies to ensure added benefit of newly approved drugs

    News22 Jul 2019|
    coast effectiveness cancer

    Janne Mewes, Anne Voermans, Bert Vrijhoef. How many of the newly approved drugs provide a substantial benefit to patients? When asking people from the general public their answer would probably be “all of them” or “the majority”. A recently published analysis conducted by researchers of the German health technology assessment agency IQWiG (Wieseler et al. […]

  • Implementation fidelity of a strategy to integrate service delivery: learnings from a transitional care program for individuals with complex needs in Singapore

    Publications18 Jul 2019|

    Research article published on BMC Health Serv Res. 2019 Mar 19 AUTHORS: Nurjono M , Shrestha P, Ang IYH, Shiraz F, Toh SESS, Vrijhoef H ABSTRACT BACKGROUND: To cope with rising demand for healthcare services in Singapore, Regional Health Systems (RHS) comprising of health and social care providers across care settings were set up to integrate […]

  • Retrospective evaluation of healthcare utilisation and mortality of two post-discharge care programmes in Singapore

    Publications22 May 2019Bert Vrijhoef|
    research paper

    Abstract Objective To evaluate the impact on healthcare utilisation frequencies and charges, and mortality of a programme for frequent hospital utilisers and a programme for patients requiring high acuity post-discharge care as part of an integrated healthcare model. Design A retrospective quasi-experimental study without randomisation where patients who received post-discharge care interventions were matched 1:1 with unenrolled […]

  • Assessment of the scientific rigour of randomized controlled trials on the effectiveness of cognitive behavioural therapy and graded exercise therapy for patients with myalgic encephalomyelitis/chronic fatigue syndrome: A systematic review

    Publications10 May 2019Bert Vrijhoef|Anam Ahmed|

    Abstract Cognitive behavioural therapy and graded exercise therapy have been promoted as effective treatments for patients with myalgic encephalomyelitis/chronic fatigue syndrome. However, criticism on the scientific rigour of these studies has been raised. This review assessed the methodological quality of studies on the effectiveness of cognitive behavioural therapy and graded exercise therapy. The methodological quality […]

  • Validation of a questionnaire measuring patient knowledge of atrial fibrillation in an Asian cohort

    Publications24 Apr 2019Bert Vrijhoef|
    Heart Asia

    Abstract BackgroundPoor patient understanding of atrial fibrillation (AF) may contribute to underuse of anticoagulation. There are no validated instruments to measure patient knowledge in Asian cohorts. This study aims to validate a disease-specific questionnaire measuring the level of understanding of AF and its treatment among patients with AF in Singapore. MethodsA 10-item interviewer-administered questionnaire was […]

  • The cost impact of PCT-guided antibiotic stewardship versus usual care for hospitalised patients with suspected sepsis or lower respiratory tract infections in the US: A health economic model analysis

    Publications23 Apr 2019Panaxea|
    antibiotics

    Abstract BackgroundProcalcitonin is a biomarker that supports clinical decision-making on when to initiate and discontinue antibiotic therapy. Several cost (-effectiveness) analyses have been conducted on Procalcitonin-guided antibiotic stewardship, but none mainly based on US originated data. ObjectiveTo compare effectiveness and costs of a Procalcitonin-algorithm versus standard care to guide antibiotic prescription for patients hospitalized with […]

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