Tag: Early-Health Technology Assessment
-
Painting the big picture for better healthcare launches
Painting the big picture for better healthcare launches Tunnel vision is a frequent problem with many health and life sciences innovators. They become immersed in a solution or design and forget about the bigger picture – what is the broader problem that the innovation seeks to solve, who will benefit from it, who are the…
-
Panaxea to investigate cost-effectiveness of innovative stem cell treatment for osteoarthritis
As part of the international consortium of the AutoCRAT (Automated Cellular Robot-Assisted Technologies, grant no. 874671) project, Panaxea is evaluating the cost-effectiveness of an innovative robot-assisted platform to manufacture stem cells that can be used to treat osteoarthritis (OA) and possibly, in the future, also other diseases. Osteoarthritis is a disease affecting millions of people…
-
Evaluating different adoption scenarios for TIL-therapy and the influence on its (early) cost-effectiveness
ABSTRACT Background: Treatment with tumor-Infiltrating Lymphocytes (TIL) is an innovative therapy for advanced melanoma with promising clinical phase I/II study results and likely beneficial cost-effectiveness. As a randomized controlled trial on the effectiveness of TIL therapy in advanced melanoma compared to ipilimumab is still ongoing, adoption of TIL therapy by the field is confronted with…
-
Early Cost-Effectiveness of Tumor Infiltrating Lymphocytes (TIL) for Second Line Treatment in Advanced Melanoma: A Model-Based Economic Evaluation
Research article published on Pubmed. 2018 Seotember 15 AUTHORS: Valesca P Retèl, Lotte M G Steuten, Marnix H Geukes Foppen, Janne C Mewes, Melanie A Lindenberg, John B A G Haanen, Wim H van Harten. ABSTRACT Background: An emerging immunotherapy is infusion of tumor infiltrating Lymphocytes (TIL), with objective response rates of around 50% versus…
-
Point-of-care diagnostic test for detecting influenza A/B and respiratory syncytial virus in the ER setting in Norway – A cost analysis
Health Technology Assessment published on EUHEA conference. 2020 June 4 AUTHOR: Anne Voermans COAUTHORS: Janne Mewes, Tove Ofstad, Thorbjørn Halvorsen, Katalin Érsek, Lotte Steuten. ABSTRACT Objectives: In Norway an average of 1.7% of the population is being diagnosed with influenza every year. New point-of-care (POC) tests for influenza A/B and RSV are available with excellent…
-
Cost-Effectiveness Analysis of a Procalcitonin-Guided Decision Algorithm for Antibiotic Stewardship Using Real-World U.S. Hospital Data.
Research article published on Pubmed. 2019 September 11 AUTHORS: Voermans AM, JC Mewes, Broyles MR, Steuten LMG. ABSTRACT Medical decision-making is revolutionizing with the introduction of artificial intelligence and machine learning. Yet, traditional algorithms using biomarkers to optimize drug treatment continue to be important and necessary. In this context, early diagnosis and rational antimicrobial therapy…
-
Cost-utility, cost-effectiveness, and budget impact of Internet-based cognitive behavioral therapy for breast cancer survivors with treatment-induced menopausal symptoms
Research article published on Springer link. 2019 August 26 AUTHORS: J.G.E. Verbeek,V. Atema, JC Mewes, M. van Leeuwen, H.S.A. Oldenburg, M. van Beurden, M.S. Hunter, W.H. van Harten, N.K. Aaronson, V.P. Retèl ABSTRACT Internet-based cognitive behavioral therapy (iCBT), with and without therapist support, is effective in reducing treatment-induced menopausal symptoms and perceived impact of…
-
Value of information analysis in telehealth for chronic heart failure management
Results of our VOI exercise show that the cost of uncertainty regarding the decision on reimbursement of telehealth interventions for chronic heart failure patients is high in the Netherlands.
-
Is procalcitonin biomarker-guided antibiotic therapy a cost-effective approach to reduce antibiotic resistant and Clostridium difficile infections in hospitalized patients?
Research article published in Omics: a journal of integrative biology, Vol. 22, No. 9 AUTHORS: Steuten L, Mewes J, Lepage-Nefkens I, Vrijhoef H ABSTRACT Antibiotics (AB) can reduce morbidity and mortality in the treatment of patients with sepsis and chronic obstructive pulmonary disease (COPD) exacerbations. Yet, AB overuse or misuse increases antibiotic resistance (ABR) and…
-
Decision analytic support model to guide implementation of laboratory assay
Panaxea to develop a decision analytic support model to guide this implementation. Interviews with key stakeholders were carried out to analyze factors that either facilitate or prevent uptake of this assay, and to identify the most important target groups.