Author: Josepha Scheffer
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Automation for Translationand Commercialization of Stem Cell-based Therapies
White Paper Abstract Advanced therapeutics such as stem cell and gene therapies are expensive whether an autologous or allogeneic product is used for patients. There is an imperative to comply with good anufacturing practice for generation of approved products as well as extensive pre-clinical and clinical testing to validate the effectiveness of advanced therapy medicinal…
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FLINT: The European Framework for Long-term Integrated care services (FLINT)
With the ongoing ageing of the European population, the demand for health and long-term care is projected to increase significantly, posing challenges for the adequacy and sustainability of health and care systems. Proactive policies focusing on the availability of long-term care services are essential to address the projected increase in demand. The Laurel project (funded…
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Understanding the Costs of Surgery: A Bottom-Up Cost Analysis of Both a Hybrid Operating Room and Conventional Operating Room
Abstract Background: Over the past decade, many hospitals have adopted hybrid operating rooms (ORs). As resources are limited, these ORs have to prove themselves in adding value. Current estimations on standard OR costs show great variety, while cost analyses of hybrid ORs are lacking. Therefore, this study aims to identify the cost drivers of a…
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Assessment of the implementation fidelity of a strategy to scale up integrated care in five European regions: a multimethod study
Abstract ObjectiveThe SCaling IntegRated Care in COntext (SCIROCCO) project tested a step-based scaling up strategy to explore what and how to scale up integrated care initiatives in five European regions. To gain a profound understanding of which factors influence the implementation of this strategy, the objective of this study was to assess the extent to…
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The transfer of knowledge on integrated care among five European regions: a qualitative multi-method study
Abstract BackgroundTo examine how the knowledge transfer processes unfolded within SCIROCCO, a EU funded project (3rd Health Programme (2014–2020)) that aimed to facilitate the process of knowledge sharing across five European regions, to speed up adoption and scaling-up of integrated care initiatives. MethodsA qualitative multi-method design was used. Data collection methods included focus groups, project…
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Improvement of shared decision making in integrated stroke care: a before and after evaluation using a questionnaire survey
Abstract BackgroundShared decision making (SDM) is at the core of policy measures for making healthcare person-centred. However, the context-sensitive nature of the challenges in integrated stroke care calls for research to facilitate its implementation. This before and after evaluation study identifies factors for implementation and concludes with key recommendations for adoption. MethodsData were collected at…
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The cost impact of PCT-guided antibiotic stewardship versus usual care for hospitalised patients with suspected sepsis or lower respiratory tract infections in the US: A health economic model analysis
Abstract BackgroundProcalcitonin is a biomarker that supports clinical decision-making on when to initiate and discontinue antibiotic therapy. Several cost (-effectiveness) analyses have been conducted on Procalcitonin-guided antibiotic stewardship, but none mainly based on US originated data. ObjectiveTo compare effectiveness and costs of a Procalcitonin-algorithm versus standard care to guide antibiotic prescription for patients hospitalized with…
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Cost-utility, cost-effectiveness, and budget impact of Internet-based cognitive behavioral therapy for breast cancer survivors with treatment-induced menopausal symptoms
Abstract PurposeInternet-based cognitive behavioral therapy (iCBT), with and without therapist support, is effective in reducing treatment-induced menopausal symptoms and perceived impact of hot flushes and night sweats (HF/NS) in breast cancer survivors. The aim of the current study was to evaluate the cost-utility, cost-effectiveness, and budget impact of both iCBT formats compared to a waiting…
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Gamen leert mensen omgaan met chronische pijn
Meer mensen bereiken met kosteneffectieve interventies is wenselijk, zodat ze leren omgaan met chronische pijn. Hiertoe zijn online en ‘blended’ vormen van gedragsveranderingsondersteuning in opkomst binnen de huisartsenzorg, geestelijke gezondheidszorg, re-integratie en pijnrevalidatie. Digitale interventies kunnen een grotere toegankelijkheid en onafhankelijke inzet van patiënten faciliteren en benodigde tijd en reisafstanden voor direct contact besparen. Leerzame…
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Assessing the maturity of the healthcare system for integrated care: testing measurement properties of the SCIROCCO tool
Abstract BackgroundThe Scaling Integrated Care in Context (SCIROCCO) tool has been developed to facilitate knowledge transfer and learning about the implementation and scaling-up of integrated care in European regions. To adequately test the functionality of the tool in assessing the maturity for integrated care within regions, this study evaluated its structural validity, internal consistency and…