At the 11th Precision Medicine World Conference in Silicon Valley (22-25 Jan), a plethora of precision medicine technologies, many of which are IT driven, were presented to a predominantly US-based audience. At the conference, the challenges that these technologies face in terms of clinical implementation (e.g. for cancer prevention, diagnosis and treatment), evidence development (e.g. early health technology assessment), and regulatory and reimbursement aspects were discussed by recognised innovation leaders, top global researchers, and medical professionals. In the magazine ICT&Health Bert Vrijhoef and Lotte Steuten wrote about the role of IT within precision medicine.