Point of Care Testing (POCT) is generally perceived to be more expensive on a unit-cost base than testing performed in a centralized laboratory. Consequently, introducing a new treatment protocol in the hospital setting, involving an increase in the number of POCT analyses performed, requires a thorough analysis of accompanying costs and benefits. Therefore, our client requested an economic evaluation of both the new and the conventional treatment protocol. To complement existing data, PANAXEA carried out a time-and-motion study to estimate additional time expenses attributed to the increase in the number of POCT analyses. We developed a health economic model integrating both deterministic and probabilistic sensitivity analyses, to recommended upon the most cost-effective protocol. To assist the dissemination of the model, we provided guidance in delivering a publication.