Diagnostics face difficulties in current market conditions to obtain reimbursement and to enter the market efficiently. This white paper highlights the challenges, but more importantly also highlights the opportunities in articulating the value of diagnostics. It is explained why tailored health economic evidence is paramount to show the value of your diagnostic innovation to several stakeholders. Available methods that can help revealing this value and how this can be used in gaining market access are presented, with an emphasis on the value of health economic evidence for manufacturers.